Familiar Workflows. New Possibilities.

Although Ikaros 7 has been completely redeveloped, its core functionality and familiar interface remain largely unchanged. This ensures that experienced Ikaros users can transition smoothly to the new version with minimal adjustment. At the same time, Ikaros 7 introduces a wide range of new features designed to make routine tasks faster and easier. As with all MetaSystems software, users remain in control - choosing which new tools and functions to integrate into their workflow.

Ikaros 7 continues to support highly adaptable processes, tailored to individual lab needs: with or without automation, with or without AI, exactly as required. Ultimately, the user remains the final decision-maker, which is why Ikaros 7 places strong emphasis on the expert’s final review and evaluation.

Highlights

• Deep Neural Networks (DNNs) assist in metaphase detection,
  chromosome segmentation and assignment, as well as band count estimation.
• The brand-new Flex Mode allows for precise correction
  and adjustment of segmentation errors during review
• A transparent and traceable confirmation workflow
  supports the validation of machine-generated karyogram proposals.
• Customizable case and cell workflow states
  ensure that all changes can be tracked in detail.
• Multiple configurable views enable
  tailored work environments for every user and every workflow stage.
• Integrated macro engine to automate repetitive actions.

Slide In. Karyogram Draft Out.

The fully automated, DNN-based workflow for creating preliminary karyogram drafts runs entirely in the background. Artificial intelligence can already assist during metaphase detection and quality sorting, enhancing the accuracy of the search results. Alongside the metaphase images, users are provided with karyogram proposals and band count estimations clearly labeled as drafts. These suggestions only become part of the official case data - and are included in reports and data summaries - once the user has explicitly approved them.

Q&A

Question: Does Ikaros 7 fully automate the creation of karyograms?
Answer: No. In the new Ikaros, the DNN capabilities facilitate the segregation of chromosomes and their categorization into the appropriate karyogram classes. This process yields a preliminary suggestion that requires further assessment and potential modification by a skilled user. Ultimately, the cytogeneticist is responsible for creating the final karyogram and conducting its analysis.

Question: Can I change the results of the DNN-based chromosome segregation and assignment?
Answer: Yes, once Ikaros generates a karyogram proposal via its DNN features, users have the possibility and the responsibility to review and, if needed, amend this proposal. They have access to the same respective tools that have been present in earlier versions of Ikaros. Nevertheless, when an appropriate DNN is utilized, it is anticipated that the need for manual adjustments will be considerably reduced compared to the machine learning algorithms used in prior versions.

Question: How much time will the new DNN-based functions save me per case or per karyogram?
Answer: The response to this inquiry is contingent on various elements. Factors such as the nature of preparations, working methods employed, and the time allocated for result verification and reporting all play crucial roles in determining processing time. Nonetheless, insights from laboratories that have adopted the new feature indicate a noticeable decrease in case processing times, attributed to the diminished requirement for manual intervention in contrast to the algorithms previously in use.

Question: Is it necessary to replace my current Ikaros installations to access the new functionalities?
Answer: No, there is no need for a replacement. Starting with version 6.3, every new version of Ikaros comes ready for DNN-based chromosome separation and classification and can be upgraded to include this feature. For efficient handling of DNN operations, an additional graphics card is needed to facilitate the computations. This card can be installed directly in the workstation or in a distinct system. For further information on the technical options available, please feel free to get in touch with us.

One Software. Every Color.

Discover the next generation of fluorescence color imaging with Ikaros 7 by MetaSystems. Built to deliver both clarity and flexibility, Ikaros 7 enhances the visualization of even the most subtle fluorescence signals, supporting precise and detailed analysis. Integrated workflows simplify complex tasks, reducing manual steps and ensuring a smooth, efficient imaging process from acquisition to evaluation.

With intuitive controls, customizable settings, and built-in automation, Ikaros 7 is designed to support users at every level - making advanced imaging more accessible without compromising on performance. Full traceability and consistent results provide the reliability needed for clinical and research environments alike, enabling users to work with greater speed, accuracy, and confidence.

Highlights

• Supports up to 12 independently acquired and processed color channels
• Each channel comes with customizable display settings,
  including display color, relative intensity, inversion, and visibility.
• Superimposed images can be displayed in four modes:
  grayscale, individual colors, blended, and false-color.
• Quick switching between two preset color modes is available.
• View settings allow multiple color modes on one screen with optional linked zoom.
• Image processing steps can be easily applied to the next image using the Repeat function.
• An unlimited number of counting functions
  enable manual recording of items (e.g., FISH signals) directly on the screen.

All Cases. Instantly Clear.

The exceptional flexibility and user-friendliness of Ikaros goes far beyond the core software itself. Every Ikaros installation includes Neon, an accessory that manages all data and workflow organization. Every image captured using Ikaros or Metafer is automatically registered, indexed, and assigned to the corresponding case by Neon. As users begin working with the image or case, Neon logs every action - providing complete transparency and allowing other team members to instantly see the current processing status.

A clean, easy-to-read case table summarizes all key information for each case on the selected data storage location. Additional details - such as patient information, user notes, or results - can be displayed as needed. Powerful yet intuitive filter and search options make it easy to locate any case in seconds. Cases can also be sorted or filtered by processing status or urgency.